Company
Since 2000, BioSign has been developing innovative measurement and therapy systems for professionals and users working with the autonomic nervous system. In doing so, BioSign reflects growing medical recognition that autonomic nervous system disorders—and disruptions in how the various organs interact with it—play a causal role in the development of many diseases.
Service list
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Dr. Reinhard D. BeiseList item 1(Managing Partner) Medical degree German Research Foundation scholarship recipient Doctorate in neurophysiology (summa cum laude; award recipient of the Städtler Foundation) Several years of university research in physiology Further training in physiology, clinical pharmacology and neurology
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Dr. Markus HoferList item 2(Shareholder) Medical degree Doctorate in ENT Clinical experience in internal medicine, trauma surgery and neonatology Several semesters of computer science studies
Beise and Hofer founded their first software company while still studying medicine and learned from the ground up through numerous projects how to turn customer requirements into working software.
Timeline
Service list
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2026 HRV-Scanner for macOSBioSign has developed a native macOS version of HRV-Scanner for the first time, for Macs with Apple silicon. This will make BioSign’s professional HRV analysis available directly on Mac, without Windows emulation. The first beta tests begin later in 2026.
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2025 Qiunity: Understanding the Rhythm of TeamsWith Qiunity, BioSign is developing a new method for visualising group cohesion and team synchronisation. The platform combines HRV technology with innovative approaches to coaching, sport and collaboration—and makes social synchronisation visible and trainable for the first time. https://www.youtube.com/watch?v=6GNFG_1gtkk
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2024 Qiu+The new Qiu+ with Bluetooth and app connectivity for Android and iOS.
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2022 BioSign HRV AppList item 2HRV biofeedback, RSA measurement and short-term HRV measurement with uploads to the myQiu server and analysis in a PDF report. Complete questionnaires configured individually by the therapist.
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2021 HRV Web ApplicationList item 3myQiu goes Web View myQiu data and measurements, including PDF reports, directly in your browser. New features, such as personalised questionnaires.
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2020 Smartphone AppsList item 4First in-house smartphone app for recording an activity log during 24-hour HRV measurement, for import into HRV-Scanner.
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2018 Advanced 24-hour analysisThe advanced 24-hour analysis gives you access to new features for an even more detailed assessment of 24-hour HRV.
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2017 HRV-Scanner plusBreathing has a major influence on HRV assessment. HRV-Scanner plus builds on the existing HRV-Scanner hardware and adds the ability to measure respiration. A pressure sensor has also been integrated for performing the Valsalva manoeuvre.
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2016 HRV-Scanner liteList item 1HRV measurement, HRV biofeedback and connectivity with myQiu/Qiu give HRV beginners everything they need for everyday clinical practice. When developing HRV-Scanner lite, we paid special attention to making the software easy and intuitive to use, including on tablets. Built-in tutorials make it even easier to use.
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2015 myQiuThe web-based HRV platform.
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2013 Flexibility-Tone-DynamicsWith its new Flexibility-Tone-Dynamics concept, BioSign brings order to the confusing array of HRV parameters and analyses. For the first time, it offers an easy-to-understand and clearly communicable model for explaining the complex processes involved in autonomic regulation.
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2010 QiuQiu is the first mobile device to let end users combine HRV measurement with HRV biofeedback.
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2008 HRV-ScannerWith HRV-Scanner, BioSign brings one of the world’s most powerful HRV measurement systems to the European market.
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2006 Stress PilotWorking with Biocomfort Diagnostics, BioSign develops Stress Pilot. It is the first HRV system in Europe to offer RSA measurement and HRV biofeedback for end users.
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2004 StressBallBioSign offers RSA measurement (respiratory sinus arrhythmia assessment, DBT = deep breathing test) through its StressBall product to practitioners across all fields. This makes a simple, low-cost test of parasympathetic function available worldwide for the first time.
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2001 fanWorking with Schwarzer (Munich), BioSign develops one of the first measurement systems for clinical autonomic function diagnostics.
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2000 FoundedBioSign GmbH founded